Mitochondrial support means all five stages of the cycle — Signal, Build, Fuel, Protect, Clear. Each product below covers one; the broadest covers two and part of a third, and leaves the rest to you. This page puts them beside Essential™ — which stages each covers, what the five cost together per day, and how many doses sit at a dose a human trial actually used.
Essential™ is the one formula that ships all five.
| Product | Stages covered | Left to you | What it does well |
|---|---|---|---|
| Tru Niagen | Build | Signal, Fuel, Protect, Clear | Multiple human RCTs on nicotinamide riboside |
| Elysium | Build | Signal, Fuel, Protect, Clear | Published trials, named scientists |
| Renue by Science | Build | Signal, Fuel, Protect, Clear | The widest NAD+ range and formats; fewer published endpoints |
| MitoQ | partial Protect | Signal, Build, Fuel, Clear, and the rest of Protect | Mitochondria-targeted delivery, demonstrated in humans |
| Timeline / Mitopure | One step of Clear | Signal, Build, Fuel, Protect, and the rest of Clear | 25 human trials over 18 years on urolithin A8 — the deepest record in the table |
| Nootropics Depot | Signal | Build, Fuel, Protect, Clear | Per-batch assays published; erinacine A stated by name on the label4 |
| Qualia Mitochondria+ | partial Build, partial Fuel, partial Protect, Clear | Signal, and the rest of Build, Fuel, and Protect | An in-house research programme; 11 of 33 actives at a studied dose9 |
| Essential™ | Signal, Build, Fuel, Protect, Clear | Nothing — all five stages are covered in full. | Every dose published next to its human study; all 15 at or above the studied dose |
Every competitor's row above equals one day at our doses, priced from their own label10. See the price →
Not a price comparison — a dose-discipline one: how much of what you buy sits at a dose a human trial used. All three figures count the doses each label publishes, ours from the Evidence page, theirs from their own panel.